The tables below describe some statistical
data on the content of the database.
These numbers were obtained on March, 2004.
|
Source distribution |
||
| Name | Mutants Found | Address |
| PubMed | 241 | http://www.ncbi.nlm.nih.gov/ |
| Swiss Prot | 236 | www.expasy.org |
| OMIM | 34 | http://www.ncbi.nlm.nih.gov/omim/ |
| Protein Mutant Database | 177 | http://spock.genes.nig.ac.jp/~pmd/ |
| Number PLPMDB entries | |
| Entry Name | Number of entries |
| Mutants | 688 |
| Mutations | 756 |
| PLP enzymes from Swiss-Prot | 1557 |
| PLP enzymes mutated | 61 |
| Protein structures | 246 |
| Refererences | 220 |
| Protein Distribution | |
|---|---|
|
Protein Name |
Number of Mutants |
| Cystathionine beta-synthase (EC 4.2.1.22) (Serine sulfhydrase) (Beta-thionase). | 86 |
| Aspartate aminotransferase (EC 2.6.1.1) (Transaminase A) (ASPAT). | 57 |
| Serine hydroxymethyltransferase (EC 2.1.2.1) (Serine methylase) (SHMT). | 39 |
| Tryptophan synthase beta chain (EC 4.2.1.20). | 35 |
| Ornithine decarboxylase (EC 4.1.1.17) (ODC). | 34 |
| 5-aminolevulinic acid synthase, erythroid-specific, mitochondrial precursor (EC 2.3.1.37) (Delta-aminolevulinate synthase) (Delta-ALA synthetase) (ALAS-E). | 31 |
| D-alanine aminotransferase (EC 2.6.1.21) (D-aspartate aminotransferase) (D-amino acid aminotransferase) (D-amino acid transaminase) (DAAT). | 29 |
| Aromatic-L-amino-acid decarboxylase (EC 4.1.1.28) (AADC) (DOPA decarboxylase) (DDC). | 29 |
| Serine hydroxymethyltransferase, cytosolic (EC 2.1.2.1) (Serine methylase) (Glycine hydroxymethyltransferase) (SHMT). | 29 |
| Serine--pyruvate aminotransferase (EC 2.6.1.51) (SPT) (Alanine-- glyoxylate aminotransferase) (EC 2.6.1.44) (AGT). | 24 |
| Ornithine aminotransferase, mitochondrial precursor (EC 2.6.1.13) (Ornithine--oxo-acid aminotransferase). | 23 |
| Cystathionine beta-lyase (EC 4.4.1.8) (CBL) (Beta-cystathionase) (Cysteine lyase). | 21 |
| Histidine decarboxylase (EC 4.1.1.22) (HDC). | 19 |
| Glycogen phosphorylase, muscle form (EC 2.4.1.1) (Myophosphorylase). | 19 |
| Tyrosine phenol-lyase (EC 4.1.99.2) (Beta-tyrosinase). | 16 |
| MalY protein [Includes: Cystathionine beta-lyase (EC 4.4.1.8) (CBL) (Beta-cystathionase) (Cysteine lyase) | 14 |
| 1-aminocyclopropane-1-carboxylate deaminase (EC 3.5.99.7) (ACC deaminase). | 13 |
| Aspartate aminotransferase, cytoplasmic (EC 2.6.1.1) (Transaminase A) (Glutamate oxaloacetate transaminase-1). | 11 |
| Glutamate-1-semialdehyde 2,1-aminomutase, chloroplast precursor (EC 5.4.3.8) (GSA) (Glutamate-1-semialdehyde aminotransferase) (GSA- AT). | 10 |
| Tryptophanase (EC 4.1.99.1) (L-tryptophan indole-lyase) (TNase). | 9 |
| 1-aminocyclopropane-1-carboxylate synthase (EC 4.4.1.14) (ACC synthase) (S-adenosyl-L-methionine methylthioadenosine-lyase). | 8 |
| D-serine dehydratase (EC 4.3.1.18) (D-serine deaminase) (DSD). | 8 |
| Lysine/ornithine decarboxylase (EC 4.1.1.18) (EC 4.1.1.17) (LDC). | 7 |
| Alanine racemase (EC 5.1.1.1). | 7 |
| 1-aminocyclopropane-1-carboxylate synthase 2 (EC 4.4.1.14) (ACC synthase 2) (S-adenosyl-L-methionine methylthioadenosine-lyase 2) (ACS-2). | 6 |
| Phosphoserine aminotransferase (EC 2.6.1.52) (PSAT). | 6 |
| Glutamate-1-semialdehyde 2,1-aminomutase (EC 5.4.3.8) (GSA) (Glutamate-1-semialdehyde aminotransferase) (GSA-AT). | 6 |
| Glycogen phosphorylase, liver form (EC 2.4.1.1). | 5 |
| Cystathionine gamma-synthase, chloroplast precursor (EC 2.5.1.48) (CGS) (O-succinylhomoserine (Thiol)-lyase). | 5 |
| Glycine dehydrogenase [decarboxylating], mitochondrial precursor (EC 1.4.4.2) (Glycine decarboxylase) (Glycine cleavage system P- protein). | 5 |
| Tryptophan synthase alpha chain | 5 |
| Glutamate decarboxylase beta (EC 4.1.1.15) (GAD-beta). | 5 |
| Histidinol-phosphate aminotransferase (EC 2.6.1.9) (Imidazole acetol- phosphate transaminase). | 4 |
| Cysteine sulfinate desulfinase (EC 4.4.1.-) (CSD). | 4 |
| 1-aminocyclopropane-1-carboxylate synthase 4 (EC 4.4.1.14) (ACC synthase 4) (S-adenosyl-L-methionine methylthioadenosine-lyase 4) (ACS-4). | 4 |
| 1-aminocyclopropane-1-carboxylate synthase 1 (EC 4.4.1.14) (ACC synthase 1) (S-adenosyl-L-methionine methylthioadenosine-lyase 1). | 3 |
| Cysteine desulfurase, mitochondrial precursor (EC 4.4.1.-) (tRNA splicing protein SPL1). | 3 |
| L-allo-threonine aldolase (EC 4.1.2.-) (L-allo-TA) (L-allo-threonine acetaldehyde-lyase). | 3 |
| L-seryl-tRNA(Sec) selenium transferase (EC 2.9.1.1) (Cysteinyl- tRNA(Sec) selenium transferase) (Selenocysteine synthase) (Selenocysteinyl-tRNA(Sec) synthase). | 3 |
| Glutamate decarboxylase, 67 kDa isoform (EC 4.1.1.15) (GAD-67) (67 kDa glutamic acid decarboxylase). | 3 |
| Cysteine synthase A (EC 2.5.1.47) (O-acetylserine sulfhydrylase A) (O- acetylserine (Thiol)-lyase A) (CSase A). | 3 |
| Formimidoyltransferase-cyclodeaminase (Formiminotransferase- cyclodeaminase) (FTCD) (LCHC1) [Includes: Glutamate formimidoyltransferase (EC 2.1.2.5) (Glutamate formiminotransferase) (Glutamate formyltransferase) | 3 |
| Threonine dehydratase biosynthetic, chloroplast precursor (EC 4.3.1.19) (Threonine deaminase) (TD). | 2 |
| Glutamate decarboxylase alpha (EC 4.1.1.15) (GAD-alpha). | 2 |
| Threonine dehydratase biosynthetic (EC 4.3.1.19) (Threonine deaminase). | 2 |
| Hemolysin | 2 |
| Cysteine synthase (EC 2.5.1.47) (O-acetylserine sulfhydrylase) (O-acetylserine (Thiol)-lyase) (CSase) (OAS-TL). | 2 |
| 1-aminocyclopropane-2-carboxylate synthase 2 (EC 4.4.1.14) (ACC synthase 2) (S-adenosyl-L-methionine methylthioadenosine-lyase 2). | 2 |
| Low-specificity L-threonine aldolase (EC 4.1.2.5) (Low-specificity L- TA). | 2 |
| Cysteine synthase (EC 2.5.1.47) (O-acetylserine sulfhydrylase) (O-acetylserine (Thiol)-lyase) (CSase A) (OAS-TL A). | 1 |
| Tyrosine aminotransferase (EC 2.6.1.5) (L-tyrosine:2-oxoglutarate aminotransferase) (TAT). | 1 |
| Selenocysteine lyase (EC 4.4.1.16) (Selenocysteine reductase) (Selenocysteine beta-lyase) (SCL). | 1 |
| 2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial precursor (EC 2.3.1.29) (AKB ligase) (Glycine acetyltransferase). | 1 |
| 4-aminobutyrate aminotransferase, mitochondrial precursor (EC 2.6.1.19) (Gamma-amino-N-butyrate transaminase) (GABA transaminase) (GABA aminotransferase) (GABA-AT) (GABA-T). | 1 |
| Methionine gamma-lyase (EC 4.4.1.11) (L-methioninase). | 1 |
| Glutamate decarboxylase, 65 kDa isoform (EC 4.1.1.15) (GAD-65) (65 kDa glutamic acid decarboxylase). | 1 |
| Aspartate aminotransferase, mitochondrial precursor (EC 2.6.1.1) (Transaminase A) (Glutamate oxaloacetate transaminase-2). | 1 |
| Glycerol dehydrogenase | 1 |
| Cysteine desulfurase (EC 4.4.1.-) (NifS protein homolog). | 1 |
| Cysteine desulfurase (EC 4.4.1.-) (ThiI transpersulfidase) (NifS protein homolog). | 1 |
| Adenosylmethionine-8-amino-7-oxononanoate aminotransferase (EC 2.6.1.62) (7,8-diamino-pelargonic acid aminotransferase) (DAPA aminotransferase). | 1 |
| Species distribution | |
|---|---|
|
Species |
Number of Mutants |
| AEROMONAS JANDAEI | 3 |
| ARABIDOPSIS THALIANA MOUSE-EAR CRESS | 9 |
| AZOTOBACTER VINELANDII | 1 |
| BACILLUS SP STRAIN YM-1 | 29 |
| BACILLUS SP STRAIN YM-2 | 4 |
| BACILLUS STEAROTHERMOPHILUS | 7 |
| BACILLUS SUBTILIS | 1 |
| BORDETELLA AVIUM | 5 |
| BOS TAURUS BOVINE | 1 |
| CANDIDA MALTOSA YEAST | 3 |
| CHLAMYDIA PNEUMONIAE CHLAMYDOPHILA PNEUMONIAE | 1 |
| CITROBACTER FREUNDII | 12 |
| CORYNEBACTERIUM GLUTAMICUM BREVIBACTERIUM FLAVUM | 2 |
| ENTEROBACTER CLOACAE | 7 |
| ERWINIA HERBICOLA | 4 |
| ESCHERICHIA COLI | 85 |
| ESCHERICHIA COLI, AND ESCHERICHIA COLI O157:H7 | 3 |
| ESCHERICHIA COLI, AND ESCHERICHIA COLI O6 | 2 |
| ESCHERICHIA COLI, AND SHIGELLA FLEXNERI | 8 |
| ESCHERICHIA COLI, ESCHERICHIA COLI O6, AND SHIGELLA FLEXNERI | 37 |
| ESCHERICHIA COLI, ESCHERICHIA COLI O6, ESCHERICHIA COLI O157:H7, AND SHIGELLA FLEXNERI | 1 |
| GALLUS GALLUS CHICKEN | 2 |
| HOMO SAPIENS HUMAN | 185 |
| KLEBSIELLA PLANTICOLA RAOULTELLA PLANTICOLA | 2 |
| LACTOCOCCUS LACTIS SUBSP. LACTIS STREPTOCOCCUS LACTIS LACTOCOCCUS LACTIS SUBSP. CREMORIS STREPTOCOCCUS CREMORIS | 16 |
| LISTERIA MONOCYTOGENES | 5 |
| LYCOPERSICON ESCULENTUM TOMATO | 10 |
| MALUS DOMESTICA APPLE MALUS SYLVESTRIS | 8 |
| MORGANELLA MORGANII PROTEUS MORGANII | 14 |
| MUS MUSCULUS MOUSE | 49 |
| NEISSERIA GONORRHOEAE | 2 |
| NEISSERIA MENINGITIDIS SEROGROUP A | 6 |
| NICOTIANA TABACUM COMMON TOBACCO | 10 |
| ORYZA SATIVA RICE | 5 |
| OVIS ARIES SHEEP | 29 |
| PROTEUS VULGARIS | 2 |
| PSEUDOMONAS PUTIDA | 1 |
| PSEUDOMONAS SP STRAIN ACP | 6 |
| PSEUDOMONAS SP STRAIN NCIMB 10558 | 2 |
| RATTUS NORVEGICUS RAT | 26 |
| Salmonella typhimurium | 5 |
| SALMONELLA TYPHIMURIUM, AND SALMONELLA TYPHI | 37 |
| SELENOMONAS RUMINANTIUM | 7 |
| SPINACIA OLERACEA SPINACH | 1 |
| SUS SCROFA PIG | 12 |
| SYNECHOCOCCUS SP STRAIN PCC 6301 ANACYSTIS NIDULANS | 4 |
| THERMUS THERMOPHILUS | 1 |
| Treponema denticola | 2 |
| TRYPANOSOMA BRUCEI BRUCEI | 6 |
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