PLPMDB Mutant Example

MUTANT ACCESSION NUMBER: 83
PROTEIN NAME: Ornithine decarboxylase (EC 4.1.1.17) (ODC).
SWISS PROT ENTRY: DCOR_MOUSE
ORGANISM: MUS MUSCULUS MOUSE
GENE NAME: ODC1 ODC
VARIANT OR MUTAGEN:Mutagen
PMD ENTRY: A982551

MUTATIONS:
POINT Asp 233 Val

EFFECTS: ODC activity [-]: Km for substrate L-ornithine [+] and cofactor pyridoxal 5''-phosphate (PLP) [+]: Ki for alpha-difluoromethyl- ornithine (DFMO) [+]: Half-life of the enzyme activity at an infinitely large concentration of DFMO [-]

REFERENCE:
PUBMED ID: 9722985
TITLE:Mutation of aspartate-233 to valine in mouse ornithine decarboxylase reduces enzyme activity.
AUTHOR:Kilpelainen PT, Hietala OA.
REFERENCE:Int J Biochem Cell Biol. 1998 Jul;30(7):803-9.

3D STRUCTURE:7ODC