PLPMDB Mutant Example

MUTANT ACCESSION NUMBER: 76
PROTEIN NAME: Tryptophanase (EC 4.1.99.1) (L-tryptophan indole-lyase) (TNase).
SWISS PROT ENTRY: TNAA_ECOLI
ORGANISM: ESCHERICHIA COLI, AND SHIGELLA FLEXNERI
GENE NAME: TNAA IND B3708 SF3754 S4017
VARIANT OR MUTAGEN:Mutagen
PMD ENTRY: A980399

MUTATIONS:
POINT Trp 330 Phe

EFFECTS: The mechanism of PLP binding to the mutant apotryptophanase differs from that for the wild-type apotryptophanase: Kinetic parameters for the fast phase [=]

REFERENCE:
PUBMED ID: 9744811
TITLE:Pyridoxal phosphate binding to wild type, W330F, and C298S mutants of Escherichia coli apotryptophanase: unraveling the cold inactivation.
AUTHOR:Erez T, Phillips RS, Parola AH.
REFERENCE:FEBS Lett. 1998 Aug 21;433(3):279-82.

3D STRUCTURE: Null