PLPMDB Mutant Example

MUTANT ACCESSION NUMBER: 23
PROTEIN NAME: Tryptophan synthase beta chain (EC 4.2.1.20).
SWISS PROT ENTRY: TRPB_SALTY
ORGANISM: SALMONELLA TYPHIMURIUM, AND SALMONELLA TYPHI
GENE NAME: TRPB STM1726 STY1325 T1638
VARIANT OR MUTAGEN:Mutagen
PMD ENTRY: A890374

MUTATIONS:
POINT Lys 87 Thr

EFFECTS: Activity in the beta reaction [0]: Formation of Schiff base with L-serine.: No other enzyme-substrate intermediates.

REFERENCE:
PUBMED ID: 2495283
TITLE:The beta subunit of tryptophan synthase. Clarification of the roles of histidine 86, lysine 87, arginine 148, cysteine 170, and cysteine 230.
AUTHOR:Miles EW, Kawasaki H, Ahmed SA, Morita H, Morita H, Nagata S.
REFERENCE:J Biol Chem. 1989 Apr 15;264(11):6280-7.

3D STRUCTURE: Null