PLPMDB Mutant Example

MUTANT ACCESSION NUMBER: 18
PROTEIN NAME: D-serine dehydratase (EC 4.3.1.18) (D-serine deaminase) (DSD).
SWISS PROT ENTRY: SDHD_ECOLI
ORGANISM: ESCHERICHIA COLI
GENE NAME: DSDA B2366
VARIANT OR MUTAGEN:Mutagen
PMD ENTRY: A880436

MUTATIONS:
POINT Gly 281 Asp

EFFECTS: Affinity for pyridoxal 5''-phosphate(PLP) [-]: Affinity for PLP-glycine complex [- -] UV absorbance (415nm) of PLP bound to DSD [-]: Fluorescence [0]: CD at 415nm of PLP-DSD [0]

REFERENCE:
PUBMED ID: 3053700
TITLE:The glycine-rich region of Escherichia coli D-serine dehydratase. Altered interactions with pyridoxal 5''-phosphate produced by substitution of aspartic acid for glycine.
AUTHOR:Marceau M, Lewis SD, Shafer JA.
REFERENCE:J Biol Chem. 1988 Nov 15;263(32):16934-41

3D STRUCTURE: Null