MUTANT ACCESSION NUMBER: 16
PROTEIN NAME: Serine hydroxymethyltransferase (EC 184.108.40.206) (Serine methylase) (SHMT).
SWISS PROT ENTRY:
ORGANISM: ESCHERICHIA COLI, ESCHERICHIA COLI O6, AND SHIGELLA FLEXNERI
GENE NAME: GLYA B2551 C3073 SF2598 S2770
VARIANT OR MUTAGEN:Mutagen
PMD ENTRY: A880266
EFFECTS: Catalytic activity [-]: Affinity for both D- and L-Ala [+]:Form quinonoid complexes with both isomers at similar rates: Transaminate both Ala isomers: Catalyze an alanine racemase reaction: Lost the ability to distinguish between D- and L-Ala.
POINT His 228 Asn
3D STRUCTURE:1EQB 1KL2
TITLE:Serine hydroxymethyltransferase: mechanism of the racemization and transamination of D- and L-alanine
AUTHOR:Shostak K, Schirch V.
REFERENCE:Biochemistry (1988) 27(21), 8007-8014
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